Resident Population in St. Francois County, MO was 67.05800 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in St. Francois County, MO reached a record high of 67.05800 in January of 2023 and a record low of 36.87500 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in St. Francois County, MO - last updated from the United States Federal Reserve on May of 2024.