Resident Population in Knox County, TN was 500.66900 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in Knox County, TN reached a record high of 500.66900 in January of 2023 and a record low of 276.29300 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Knox County, TN - last updated from the United States Federal Reserve on May of 2024.